Saddiq Bey had 23 points, one more than 2021 No. 1 draft pick Cade Cunningham.
Detroit also beat the Raptors on Jan. 14, 103-87, at Michigan.
Cunningham added 12 rebounds for the Pistons, who have won four of their last six games.
He also had four game-high three-pointers.
Ontarian Cory Joseph led his team with six assists, including a steal and a block.
Pascal Siakam led the Raptors with 28 points.
Scottie Barnes provided 21, Precious Achiuwa 18 and Gary Trent 14.
The Raptors will play again Friday night at home against the Orlando Magic.
Siakam approached Toronto at 106-104 with a stride shot with 56 seconds on the clock.
With 37 seconds to go, Achiuwa had a chance to level the score, but only managed one free throw.
Bey followed it up with a basket, then the visitors stayed the course.
Fred VanVleet was sidelined for the third straight game with a right knee contusion. OG Anunoby was missing for a fifth game in a row after fracturing his right ring finger.
The Raptors were also playing without Thad Young (non-COVID-19 illness). The reserve has scored 10, 11 and 11 points in his last three games.
Nick Nurse’s group is 7th in the East, two games behind the 6th-placed Cleveland Cavaliers.
Barnes was also named February’s Rookie of the Month in the East.
He set a career-high 28 points on Feb. 25 in Charlotte.
Three days later, he again had 28 points and set a career high with 16 rebounds in Brooklyn.
In that game, he made his first 11 shots in continuous play. Barnes also had five steals in the matchup.
For the first time since Shaquille O’Neal in 1993, a rookie had at least 25 points, 15 rebounds and 5 steals in a game.
Drafted fourth last year, Barnes averaged 15.2 points per game in February.
In the West, the rookie of the month is Josh Giddey of the Oklahoma City Thunder. He averaged 16.3 points per game. The 19-year-old Australian led rookies with 8.7 rebounds and 7.7 assists, on average.
