●Diabetes Specialist / Instructor Takashi Nomiyama | Column on Diabetes
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The true value, superiority and inferiority, and good and evil of things are usually passed on to posterity by twisting the truth by those in power at the time. The taiga drama “Kirin ga Kuru” currently being broadcast is about to reflect the true appearance of the great sinner Akechi Mitsuhide in the history of defeating Nobunaga Oda. Furthermore, it is common in the world of science that values change depending on the background of life and the increase and decrease of diseases. The insulin introduced in the heavy ❗️ total length 22 cm ❗️ bike figure rare ❗️ was Miracle Luck at the time of discovery, but recently there is a concern that excessive chronic hyperinsulinemia may promote arteriosclerosis and cancer. be. Adrenaline has also recently been seen as a bad guy who contributes to the development of cardiovascular events during hypoglycemia, but it must have been an important hormone for our ancestors who were hunting early in the morning. Time & Style, which releases a large amount of adrenaline, is a custom-made beauty product. The fact that hereditary diseases (such as MEN2 type) with a list price of over 2 million have an autosomal dominant inheritance may be one of the supporting evidences. unknown.
(GLP-1) is a hormone that lowers blood sugar levels, people living in modern society with many diabetics would say. In fact, some papers have reported that GLP-1 and Fibroblast growth factor 21 (FGF21) lower blood glucose levels in the absence of insulin. On the other hand, we have reported the vasoprotective effect of GLP-1 and the suppressive effect of cancers such as prostate cancer, and call it a beyond effect that goes beyond the hypoglycemic effect (Adidas Harden 5 Creator). But which is Beyond? Based on the clinically applied timeline and the number of patients, it is said that diabetes drugs suppress prostate cancer with Beyond action, but if the opposite is true, prostate cancer drugs go beyond the cancer suppressive action and lower blood glucose. I might have been told. Since we reported the prostate cancer inhibitory effect of GLP-1 in the unprecedented Diabetes magazine in the history of Fukuoka University, papers supporting this have been reported all over the world. It is reported that the GLP-1 action enhances the effect of enzalutamide and docetaxel, which are therapeutic agents for prostate cancer, enhances the response to radiation therapy for prostate cancer, and may be used as a ligand in PET testing for prostate cancer. be. And recently we have reached one ultimate research result. Even in prostate cancer cells that do not have endogenous GLP-1 receptor expression, forced expression of the GLP-1 receptor has a growth inhibitory effect, and in human prostate cancer, GLP-1 receptor expression is initially obtained. However, it turned out that it would not be recognized as it progressed. This report was also taken up on a medical site and attracted attention. Of particular interest are human data.
In fact, GLP-1 receptors are not expressed in normal prostate tissue. At lectures, we are often asked the question, “Why does prostate cancer develop receptors that are detrimental to cancer?” At that time, I jokingly answered, “Isn’t cancer also self-control?”, But when I think about it now, it may have been a name (stray) answer. Recall the common zombie movies in the United States. A friend of the hero tells the hero almost always, “If I become a zombie, shoot without hesitation.” And, unfortunately, when he becomes a zombie, he says “I told you to shoot, shoot early” at the beginning, but gradually he loses his reason and becomes a zombie that attacks the hero. Perhaps this “shoot” friend’s cry of conscience is the expression of the GLP-1 receptor in prostate cancer. In addition to prostate cancer, GLP-1 receptors are expressed, and the tumor suppressor effect of GLP-1 has been reported by us and other groups. There may be many other cancer cells whose friends are crying for their last conscience.
On the other hand, it is feared that the new coronavirus will be rampant and become more severe in diabetic patients, but infectious diseases are the second leading cause of death in diabetic patients after malignant neoplasm (cancer). And there are also interesting reports on infectious diseases and GLP-1. It has been reported that administration of lipopolysaccharide (LPS), a type of endotoxin that causes multiple organ failure in severe infections, increases GLP-1 secretion from small intestinal L cells. ing. The purpose of GLP-1 issued at this time is definitely not to lower blood sugar. So why is GLP-1 action required in life-threatening situations such as cancer and severe infections? My answer is that I personally think that the true purpose of GLP-1 is to rescue life from crisis situations. The first formulated GLP-1 receptor agonist exenatide was also originally intended to save the gila monster from the crisis of starvation.
There are two last things I would like to add. First, it is not that the new coronavirus is more likely to be severe in diabetics. And then, episode 27 is a complete delusional theater of the author, and I understand that it was wrong to administer a GLP-1 receptor agonist for the purpose of clinically controlling cancer and severe infections. I would like you to do it. 100 years later, which position will Sugar King be in, Oda Nobunaga, Akechi Mitsuhide, Toyotomi Hideyoshi, and Tokugawa Ieyasu? I’m looking forward to it.
As a kendo artist, I like history. Also, under the influence of my grandparents, I like shrines and shrines, and when I travel, I visit the surrounding temples and shrines to contribute to the maintenance of historical buildings to some extent. Previously, when Sanada Maru was aired in a taiga drama, I went to Ueda with his wife and mother-in-law. There is a beautiful historical cityscape and a temple called Anrakuji when you take a walk while enjoying the hot springs, and I visited it as usual. Then there was one big folding screen painting, which was a reproduction of the Siege of Osaka folding screen painting. And when I looked closely, I found it. It is an ancestor of the Nomiyama family. I heard from my grandmother that the ancestors of the Nomiyama family were samurai who served the Kuroda family. However, a military commander with the flag of “Difference Yamagata”, which is the family crest of our family, is participating in the Osaka summer camp.
I’m not sure if it’s really my ancestor, but I thank my grandmother in my heart. Since my ancestor was a vassal of the Kuroda clan, Ieyasu Tokugawa was the winner. It seems that he was much better at the world than I was.
[● Shipping included ● BALENCIAGA ● Dot skirt]Words used in Japanese martial arts and arts. Sometimes written as zanshin or zanshin. When interpreted literally, it means that the mind is uninterrupted. Shows consciousness, especially after finishing the technique, while relaxing or relaxing. It is also a concept related to Japanese aesthetics and Zen, such as leaving a lingering finish rather than ending and forgetting at the same time as the technique. (Partially excerpted and reprinted from Wikipedia)
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[Episode 37]Oral GLP-1 receptor agonist
